VIVOTIF® (Typhoid Vaccine Live Oral Ty21a)

Type of Vaccine:
Live, attenuated bacteria (Ty21a strain)

Dosage Form:
• Vaccine should be taken on an empty stomach (ie, 1 hour before eating) to avoid delaying passage of vaccine through stomach. Many patients find it's easiest to take at bedtime.
• Do not consume alcohol within 1 hour of taking the vaccine

Route of Administration:
Oral. It stimulates both local immunity in the gut at the site of potenial typhoid infection, and systemic immunity. Ty21a is completely adsorbed in the ileum, with no excretion in the feces. Therefore, there is no risk of contaminating other family members.

Age:
6 years & older

Immunization:
4 doses (1 taken every other day)

Effectiveness:
50-80% (per CDC; 55-74% per ACIP)

Length of Protection:
5 years
Long term studies confirm Ty21a protection does not diminish over this 5 year period

Vaccination Timing:
Complete regimen 1 week before potential exposure

Concommitant Medications/Vaccinations:
Mefloquine
Chloroquine
OPV
Yellow Fever vaccine
Immune Globulin

Contraindications:
Immunocompromised patients
Patient taking antibiotics
Patient with fever, vomiting or diarrhea

Storage:
Store in refrigerator until time to take each dose. Return remaining doses to refrigerator.

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Full Prescribing Informtion
Information on ORAL ROUTE of immunization
Frequently asked QUESTIONS AND ANSWERS